Article
Interaction between 25S rRNA A loop and eukaryotic translation initiation factor 5B promotes subunit joining and ensures stringent AUG selection.
Molecular and cellular biology - 1 Sept 2013
Hiraishi Hiroyuki, Shin Byung-Sik, Udagawa Tsuyoshi, Nemoto Naoki, Chowdhury Wasimul, Graham Jymie, Cox Christian, Reid Megan, Brown Susan J, Asano Katsura
Abstract excerpt
In yeast, 25S rRNA makes up the major mass and shape of the 60S ribosomal subunit. During the last step of translation initiation, eukaryotic initiation factor 5B (eIF5B) promotes the 60S subunit joining with the 40S initiation complex (IC). Malfunctional 60S subunits produced by misfolding or mutation may disrupt the 40S IC stalling on the start codon, thereby altering the stringency of initiation. Using several...
Topics
- Basic-Leucine Zipper Transcription Factors
- Codon, Initiator
- Eukaryotic Initiation Factors
- Genes, Fungal
- Models, Molecular
- Mutation
- Nucleic Acid Conformation
- Peptide Chain Initiation, Translational
- Peptidyl Transferases