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Article

A conformational switch in initiation factor 2 controls the fidelity of translation initiation in bacteria.

Nature communications - 14 Nov 2017

Caban Kelvin, Pavlov Michael, Ehrenberg Måns, Gonzalez Ruben L

Abstract excerpt

Initiation factor (IF) 2 controls the fidelity of translation initiation by selectively increasing the rate of 50S ribosomal subunit joining to 30S initiation complexes (ICs) that carry an N-formyl-methionyl-tRNA (fMet-tRNAfMet). Previous studies suggest that rapid 50S subunit joining involves a GTP- and fMet-tRNAfMet-dependent "activation" of IF2, but a lack of data on the structure and conformational dynamics...

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Identifiers

PMID: 29133802
DOI: 10.1038/s41467-017-01492-6
PMCID: PMC5684235

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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A conformational switch in initiation factor 2 controls the fidelity of translation initiation in bacteria.PMID 29133802Read ↗

Activation of initiation factor 2 by ligands and mutations for rapid docking of ribosomal subunits.Semantic proximity Read ↗

Characterization of 16S rRNA mutations that decrease the fidelity of translation initiation.Semantic proximity Read ↗

Two highly conserved features of bacterial initiator tRNAs license them to pass through distinct checkpoints in translation initiation.Semantic proximity Read ↗

Role of helix 44 of 16S rRNA in the fidelity of translation initiation.Semantic proximity Read ↗

Translation initiation without IF2-dependent GTP hydrolysis.Semantic proximity Read ↗

A single mutation in the IF3 N-terminal domain perturbs the fidelity of translation initiation at three levels.Semantic proximity Read ↗

Uncoupling of initiation factor eIF5B/IF2 GTPase and translational activities by mutations that lower ribosome affinity.Semantic proximity Read ↗

Weakening the IF2-fMet-tRNA Interaction Suppresses the Lethal Phenotype Caused by GTPase Inactivation.Semantic proximity Read ↗

Structure of a specialized 70S initiation complex.Semantic proximity Read ↗

Roles of helix H69 of 23S rRNA in translation initiation.Semantic proximity Read ↗

IF2 and unique features of initiator tRNAfMet help establish the translational reading frame.Semantic proximity Read ↗

Control of translation initiation involves a factor-induced rearrangement of helix 44 of 16S ribosomal RNA.Semantic proximity Read ↗

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