Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Molecular view of 43 S complex formation and start site selection in eukaryotic translation initiation.

The Journal of biological chemistry - 9 Jul 2010

Lorsch Jon R, Dever Thomas E

Abstract excerpt

A central step to high fidelity protein synthesis is selection of the proper start codon. Recent structural, biochemical, and genetic analyses have provided molecular insights into the coordinated activities of the initiation factors in start codon selection. A molecular model is emerging in which start codon recognition is linked to dynamic reorganization of factors on the ribosome and structural changes in the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Codon, Initiator
Share to Eukaryotic Initiation Factor-2
Share to Peptide Chain Initiation, Translational

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Peptide Initiation Factors

Share to Protein Biosynthesis

Share to Protein Conformation

Share to Ribosomes

Share to RNA-Binding Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 20444698
DOI: 10.1074/jbc.R110.119743
PMCID: PMC2898419

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Molecular view of 43 S complex formation and start site selection in eukaryotic translation initiation.PMID 20444698Read ↗

Structure of a specialized 70S initiation complex.Semantic proximity Read ↗

Mechanisms Leading to the Loss of AUG Codon Function as a Translation InitiatorSemantic proximity Read ↗

Molecular Landscape of the Ribosome Pre-initiation Complex during mRNA Scanning: Structural Role for eIF3c and Its Control by eIF5.Semantic proximity Read ↗

eIF5 and eIF5B together stimulate 48S initiation complex formation during ribosomal scanning.Semantic proximity Read ↗

Molecular architecture of 40S translation initiation complexes on the hepatitis C virus IRESSemantic proximity Read ↗

Decoding the Sequence Requirements for Translation InitiationSemantic proximity Read ↗

Role of helix 44 of 16S rRNA in the fidelity of translation initiation.Semantic proximity Read ↗

Rps3/uS3 promotes mRNA binding at the 40S ribosome entry channel and stabilizes preinitiation complexes at start codons.Semantic proximity Read ↗

The C-terminal domain of eukaryotic initiation factor 5 promotes start codon recognition by its dynamic interplay with eIF1 and eIF2β.Semantic proximity Read ↗

A codon-sensitive conformational switch gates commitment to translation start sitesSemantic proximity Read ↗

Interaction between 25S rRNA A loop and eukaryotic translation initiation factor 5B promotes subunit joining and ensures stringent AUG selection.Semantic proximity Read ↗

The structure of a human translation initiation complex reveals two independent roles for the helicase eIF4ASemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.