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Article

Role of helix 44 of 16S rRNA in the fidelity of translation initiation.

RNA (New York, N.Y.) - 1 Mar 2012

Qin Daoming, Liu Qi, Devaraj Aishwarya, Fredrick Kurt

Abstract excerpt

The molecular mechanisms that govern translation initiation to ensure accuracy remain unclear. Here, we provide evidence that the subunit-joining step of initiation is controlled in part by a conformational change in the 1408 region of helix h44. First, chemical probing of 30S initiation complexes formed with either a cognate (AUG) or near-cognate (AUC) start codon shows that an IF1-dependent enhancement at A1408...

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Identifiers

PMID: 22279149
DOI: 10.1261/rna.031203.111
PMCID: PMC3285936

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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