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Article

Effectiveness of colorectal cancer screening integrating non-genetic and genetic risk: a prospective study based on UK Biobank data.

Cancer biology & medicine - 20 Jun 2024

Zhang Yu, Sheng Chao, Lyu Zhangyan, Dai Hongji, Song Fangfang, Song Fengju, Huang Yubei, Chen Kexin

Abstract excerpt

OBJECTIVE: Few studies have evaluated the benefits of colorectal cancer (CRC) screening integrating both non-genetic and genetic risk factors. Here, we aimed to integrate an existing non-genetic risk model (QCancer-10) and a 139-variant polygenic risk score to evaluate the effectiveness of screening on CRC incidence and mortality. METHODS: We applied the integrated model to calculate 10-year CRC risk for 430,908...

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Identifiers

PMID: 38899940
DOI: 10.20892/j.issn.2095-3941.2024.0096
PMCID: PMC11359493

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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