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Article

Effects of Screenings in Reducing Colorectal Cancer Incidence and Mortality Differ by Polygenic Risk Scores.

Clinical and translational gastroenterology - 6 May 2021

Choi Jungyoon, Jia Guochong, Wen Wanqing, Long Jirong, Shu Xiao-Ou, Zheng Wei

Abstract excerpt

INTRODUCTION: Colorectal cancer (CRC) screening reduces CRC incidence and mortality. However, it is unclear whether the reduction in CRC risk may differ by genetic susceptibility. METHODS: We evaluated this question in a cohort of 304,740 participants of European descent aged 50 years and older. Genetic susceptibility was measured using a polygenic risk score (PRS) constructed with risk variants identified in...

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Identifiers

PMID: 33955373
DOI: 10.14309/ctg.0000000000000344
PMCID: PMC8104134

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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