Article
Lupus acceleration by a MAVS-activating RNA virus requires endosomal TLR signaling and host genetic predisposition.
PloS one - 1 Jan 2018
Gonzalez-Quintial Rosana, Nguyen Anthony, Kono Dwight H, Oldstone Michael B A, Theofilopoulos Argyrios N, Baccala Roberto
Abstract excerpt
Viruses have long been implicated in the pathogenesis of autoimmunity, yet their contribution remains circumstantial partly due to the lack of well-documented information on infections prior to autoimmune disease onset. Here, we used the lymphocytic choriomeningitis virus (LCMV) as a model to mechanistically dissect the impact of viral infection on lupus-like autoimmunity. Virus persistence strongly enhanced...
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