Article
Negative Epistasis and Evolvability in TEM-1 β-Lactamase--The Thin Line between an Enzyme's Conformational Freedom and Disorder.
Journal of molecular biology - 17 Jul 2015
Dellus-Gur Eynat, Elias Mikael, Caselli Emilia, Prati Fabio, Salverda Merijn L M, de Visser J Arjan G M, Fraser James S, Tawfik Dan S
Abstract excerpt
Epistasis is a key factor in evolution since it determines which combinations of mutations provide adaptive solutions and which mutational pathways toward these solutions are accessible by natural selection. There is growing evidence for the pervasiveness of sign epistasis--a complete reversion of mutational effects, particularly in protein evolution--yet its molecular basis remains poorly understood. We describe...
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