Article
Patterns of Epistasis between beneficial mutations in an antibiotic resistance gene.
Molecular biology and evolution - 1 Aug 2013
Schenk Martijn F, Szendro Ivan G, Salverda Merijn L M, Krug Joachim, de Visser J Arjan G M
Abstract excerpt
Understanding epistasis is central to biology. For instance, epistatic interactions determine the topography of the fitness landscape and affect the dynamics and determinism of adaptation. However, few empirical data are available, and comparing results is complicated by confounding variation in the system and the type of mutations used. Here, we take a systematic approach by quantifying epistasis in two sets of...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.