Understanding epistatic networks in the B1 β-lactamases through coevolutionary statistical modeling and deep mutational scanning.

Abstract excerpt

Throughout evolution, protein families undergo substantial sequence divergence while preserving structure and function. Although most mutations are deleterious, evolution can explore sequence space via epistatic networks of intramolecular interactions that alleviate the harmful mutations. However, comprehensive analysis of such epistatic networks across protein families remains limited. Thus, we conduct a family...

Topics

Join the communities discussing this publication.

• beta-Lactamases
• Epistasis, Genetic
• Evolution, Molecular
• Models, Molecular
• Models, Statistical