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Article

DNA Methylation Stochasticity Is Linked to Transcriptional Variability and Convergent Epigenetic Disruption across Genetic Subtypes of Acute Myeloid Leukemia.

Cancer research - 2 Jul 2026

Hilgart Eleanor, Zhou Weiqiang, Martinez-Montes Eduardo, Tryggvadottir Rakel, Gondek Lukasz P, Majeti Ravindra, Ji Hongkai, Koldobskiy Michael A, Feinberg Andrew P

Abstract excerpt

Disruption of the epigenetic landscape is of particular interest in acute myeloid leukemia (AML) due to its relatively low mutational burden and frequent occurrence of mutations in epigenetic regulators. In this study, we applied an information-theoretic analysis of methylation potential energy landscapes, capturing changes in mean methylation level and methylation entropy, to comprehensively analyze DNA...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41838954
DOI: 10.1158/0008-5472.CAN-25-5822
PMCID: PMC13148364

Genes

IDH2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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