Article

Computational modeling of methylation impact of AML drivers reveals new pathways and refines AML risk-stratification

2023-05-21

Abstract excerpt

<h4>ABSTRACT</h4> Decades before its clinical onset, epigenetic changes start to accumulate in the progenitor cells of Acute Myelogenous Leukemia (AML). Delineating these changes can improve risk-stratification for patients and shed insights into AML etiology, dynamics and mechanisms. Towards this goal, we extracted “epigenetic signatures” through two parallel machine learning approaches: a supervised regression...

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Literature Corpus work: 6d5bfd81-9ba3-5c88-a28d-9b5e07f694d4
DOI: 10.1101/2023.05.17.541249

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