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Article

Global epistasis in budding yeast driven by many natural variants whose effects scale with fitness.

Genetics - 8 Oct 2025

Goldstein Ilan, Hale Joseph J, Ehrenreich Ian M

Abstract excerpt

Global epistasis is a phenomenon in which the effects of genetic perturbations depend on the fitness of the individuals in which they occur. In populations with natural genetic variation, global epistasis arises from interactions between perturbations and polymorphic loci that are mediated by fitness. To investigate the prevalence and characteristics of loci involved in these interactions in the budding yeast...

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Identifiers

PMID: 40679398
DOI: 10.1093/genetics/iyaf136
PMCID: PMC12505298

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