Article
Alpha-Klotho-deficient female mice exhibit estrogen metabolic dysregulation and a premature ovarian insufficiency-like phenotype.
Molecular and cellular endocrinology - 1 Jul 2026
Feng Dan, Chen Jiaxin, Li Yalan, Huang Biao, Chen Zhi, Li Xin
Abstract excerpt
BACKGROUND: Premature ovarian insufficiency (POI) is characterized by early loss of ovarian function, hypoestrogenism, and infertility. α-Klotho, an aging-suppressor protein, has been implicated in reproductive aging, but its role in POI and ovarian steroidogenesis remains unclear. METHODS: Systemic α-Klotho KO female mice and age-matched WT were evaluated by ovarian histology, estrous cycle monitoring, serum...
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