Article

Single-cell exploration of ovarian aging across vertebrate models

2025-10-15

Abstract excerpt

Mammalian female reproductive span is thought to be limited by a fixed “ovarian reserve” determined at birth. With age, a dwindling ovarian reserve leads to infertility, culminating in menopause in humans. In addition to infertility, accumulating evidence has shown that age-related ovarian functional decline contributes to multisystem aging and frailty, making post-menopausal women most susceptible to an array of...

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Literature Corpus work: 59697243-6b65-55d7-aa26-bb830348cc29
DOI: 10.1101/2025.10.15.682639

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