Distinct HPO axis responses and ovarian aging trajectories to chronic unpredictable mild stress in reproductively young versus middle-aged female mice

Abstract excerpt

Psychosocial stressors are key contributors to ovarian functional decline. Chronic unpredictable mild stress (CUMS) is widely used to model stress-induced premature ovarian insufficiency (POI) in mice; however, current animal models do not adequately reflect middle-aged women, who represent a key population exposed to chronic psychosocial stress, nor do they capture the dynamic progression toward POI. Here, female...

Topics

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• Circadian Rhythm
• Gonadal Steroid Hormones
• Hypothalamo-Hypophyseal System
• Mice
• Mice, Inbred ICR
• Ovary
• Pituitary-Adrenal System
• Polycystic Ovary Syndrome

Identifiers and source

Literature Corpus work

c5eb4927-1bde-5db3-a98c-2c1f8bdceb5b

DOI

10.64898/2026.04.24.720585