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Article

Dissection of transcriptomic and epigenetic heterogeneity of grade 4 gliomas: implications for prognosis.

Acta neuropathologica communications - 14 Aug 2023

Zeng Chang, Song Xiao, Zhang Zhou, Cai Qinyun, Cai Jiajun, Horbinski Craig, Hu Bo, Cheng Shi-Yuan, Zhang Wei

Abstract excerpt

BACKGROUND: Grade 4 glioma is the most aggressive and currently incurable brain tumor with a median survival of one year in adult patients. Elucidating novel transcriptomic and epigenetic contributors to the molecular heterogeneity underlying its aggressiveness may lead to improved clinical outcomes. METHODS: To identify grade 4 glioma -associated 5-hydroxymethylcytosine (5hmC) and transcriptomic features as well...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 37580817
DOI: 10.1186/s40478-023-01619-5
PMCID: PMC10426201

Genes

IDH1

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