Article
Diffuse Isocitrate Dehydrogenase-Mutant Gliomas With Histone H3 Alterations Are Distinguished by Unique Clinical Characteristics, Molecular Expression Profile, and Survival Prognosis.
Neurosurgery - 1 Oct 2023
Cheng Cheng, Wang Di, Yu Mingchen, Zhai You, Pan Changqing, Liang Bo, Zhang Jiazheng, Wang Chen, Yin Yiyun, Li Lianwang, Wu Fan, Shi Zhongfang, Fan Xing, Liu Xing, Wang Zhiliang, Zhao Zheng, Li Guanzhang, Jiang Tao, Zhang Wei
Abstract excerpt
BACKGROUND AND OBJECTIVES: Histopathological features and molecular biomarkers have been studied as potential prognostic factors. This study aimed to investigate the clinical features, molecular phenotypes, and survival prognosis of isocitrate dehydrogenase (IDH)-mutant (IDHmt) gliomas with histone H3 alterations (H3-alterations). METHODS: A total of 236 and 657 patients with whole-exome sequencing data were...
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