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Article

From variants to mechanisms: Neurogenomics in the post-GWAS era.

Neuron - 5 Nov 2025

Margolis Michael P, Tang Miao, Gagliardi Miriam, Wen Cindy, Wu Yeda, Wray Naomi R, Ziller Michael J, Gandal Michael J

Abstract excerpt

Genome-wide association studies (GWASs) have identified thousands of variants associated with neuropsychiatric disorders (NPDs), including autism spectrum disorder (ASD), schizophrenia (SCZ), and Alzheimer's disease (AD). However, deciphering the "causal" biological mechanisms and pathways through which these variants act remains a major obstacle that hinders translational understanding of NPD pathogenesis. NPDs...

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Identifiers

PMID: 41197609
DOI: 10.1016/j.neuron.2025.10.014
PMCID: PMC12626417

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