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Article

Role of α-Synuclein Regions in Nucleation and Elongation of Amyloid Fiber Assembly.

ACS chemical neuroscience - 18 Mar 2020

Gallardo José, Escalona-Noguero Carmen, Sot Begoña

Abstract excerpt

α-Synuclein is an intrinsically disordered protein whose aggregation in the form of amyloid fibers is directly implicated in Parkinson's disease and other neurological disorders. α-Synuclein is composed of three different regions. The central region (61-95), called NAC, is responsible for protein fibrillation. The N-terminal region (1-61) has some helical propensity and can be divided into H1 (1-31) and H2...

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PMID: 32078298
DOI: 10.1021/acschemneuro.9b00527

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