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Article

Impact of Ethnicity on the Uptake of Risk Reducing Mastectomy in Unaffected BRCA1/2 and PALB2 Carriers in Canada.

Annals of surgical oncology - 1 Jun 2026

Mashal Sarah, Melanson Amel, Apostolova Carla, Ferroum Amina, Villareal-Corpuz Victor, Meterissian Sarkis, Martel Karyne, Boileau Jean-François, Basik Mark, Foulkes William, Wong Stephanie M, Prakash Ipshita

Abstract excerpt

BACKGROUND: While several studies have reported on factors influencing the uptake of risk-reducing mastectomy (RRM) in patients with germline pathogenic variants (gPV) in BRCA1/2, there remains a paucity of data regarding variations in uptake by ethnicity. METHODS: We conducted a retrospective cohort study of unaffected female patients with a confirmed gPV in BRCA1/2 or PALB2 between March 2000 to March 2023 at...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41811390
DOI: 10.1245/s10434-026-19375-w

Genes

BRCA1
PALB2
BRCA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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