Article
BRCA1/2 mutations and risk-reducing bilateral salpingo-oophorectomy among Latinas: The UPTAKE study.
Journal of genetic counseling - 1 Apr 2021
Lynce Filipa, Schlam Ilana, Geng Xue, Peshkin Beth N, Friedman Sue, Dutil Julie, Nahleh Zeina, Campos Claudia, Ricker Charité, Rodriguez Patricia, Denduluri Neelima, Ahn Jaeil, Isaacs Claudine, Graves Kristi D
Abstract excerpt
Bilateral salpingo-oophorectomy (BSO) is a risk management approach with strong evidence of mortality reduction for women with germline mutations in the tumor suppressor genes BRCA1 and BRCA2 (BRCA1/2). Few studies to date have evaluated uptake of BSO in women from diverse racial and ethnic backgrounds who carry BRCA1/2 mutations. The objective of the UPTAKE study was to explore rates and predictors of...
Topics
- BRCA1 Protein
- BRCA2 Protein
- Breast Neoplasms
- Female
- Genetic Predisposition to Disease
- Hispanic or Latino
- Humans
- Mutation
- Ovarian Neoplasms
- Ovariectomy