Uptake of risk-reducing medical interventions among female BRCA1/2 pathogenic variant carriers: A population-based study in British Columbia.

doi:10.1016/j.ygyno.2026.05.018

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Article

Uptake of risk-reducing medical interventions among female BRCA1/2 pathogenic variant carriers: A population-based study in British Columbia.

Gynecologic oncology - 1 Jul 2026

Lloyd-Ellis Sabrina, Kaur Paramdeep, Kwon Janice S, Dawson Lesa, Hanley Gillian E

Abstract excerpt

OBJECTIVE: Being a female with a germline BRCA1 or BRCA2 pathogenic variant (PV) elevates risks of developing breast and ovarian cancer, and guidelines recommend preventive interventions and increased screening. This study assesses the use of risk-reducing interventions. METHODS: This population-based retrospective study included all females who tested positive for a BRCA1/2 PV in British Columbia between 1996...

Topics

Humans
Female
British Columbia
Ovarian Neoplasms
Retrospective Studies
Middle Aged
Breast Neoplasms
Adult
Salpingo-oophorectomy
Genes, BRCA2
Germ-Line Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Risk Reduction Behavior

Genetic Predisposition to Disease

Aged

BRCA2 Protein

Genes, BRCA1

BRCA1 Protein

Heterozygote

Source

Open in PubMed

Identifiers

PMID: 42166900
DOI: 10.1016/j.ygyno.2026.05.018

Genes

BRCA1
BRCA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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