Timing of genetic testing in BRCA1/2 and PALB2-Associated breast cancer: Preoperative result disclosure increases uptake of risk-reducing mastectomy and reduces unnecessary exposure to radiotherapy.

doi:10.1016/j.ejso.2024.108324

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Timing of genetic testing in BRCA1/2 and PALB2-Associated breast cancer: Preoperative result disclosure increases uptake of risk-reducing mastectomy and reduces unnecessary exposure to radiotherapy.

European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology - 1 Jun 2024

Apostolova Carla, Ferroum Amina, Alhassan Basmah, Prakash Ipshita, Basik Mark, Boileau Jean Francois, Martel Karyne, Meterissian Sarkis, Villareal Corpuz Victor, Wong Nora, Foulkes William D, Wong Stephanie M

Abstract excerpt

INTRODUCTION: The impact of timing of genetic testing on uptake of risk reducing mastectomy (RRM) in affected female BRCA1/2 or PALB2 carriers remains an area of evolving interest, particularly with the introduction of mainstream genetic testing initiatives. METHODS: Women with stage I-III breast cancer and a confirmed germline pathogenic variant in BRCA1/2 or PALB2 between 2000 and 2023 were identified from an...

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PMID: 38636249
DOI: 10.1016/j.ejso.2024.108324

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BRCA1
PALB2

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