Timing of genetic testing in BRCA1/2 and PALB2-Associated breast cancer: Preoperative result disclosure increases uptake of risk-reducing mastectomy and reduces unnecessary exposure to radiotherapy.

doi:10.1016/j.ejso.2024.108324

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Article

Timing of genetic testing in BRCA1/2 and PALB2-Associated breast cancer: Preoperative result disclosure increases uptake of risk-reducing mastectomy and reduces unnecessary exposure to radiotherapy.

European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology - 1 Jun 2024

Apostolova Carla, Ferroum Amina, Alhassan Basmah, Prakash Ipshita, Basik Mark, Boileau Jean Francois, Martel Karyne, Meterissian Sarkis, Villareal Corpuz Victor, Wong Nora, Foulkes William D, Wong Stephanie M

Abstract excerpt

INTRODUCTION: The impact of timing of genetic testing on uptake of risk reducing mastectomy (RRM) in affected female BRCA1/2 or PALB2 carriers remains an area of evolving interest, particularly with the introduction of mainstream genetic testing initiatives. METHODS: Women with stage I-III breast cancer and a confirmed germline pathogenic variant in BRCA1/2 or PALB2 between 2000 and 2023 were identified from an...

Topics

Humans
Female
Breast Neoplasms
Fanconi Anemia Complementation Group N Protein
Genetic Testing
Adult
Middle Aged
Prophylactic Mastectomy

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Germ-Line Mutation

Disclosure

Mastectomy

Time Factors

Heterozygote

Genes, BRCA2

BRCA1 Protein

Genetic Predisposition to Disease

Genes, BRCA1

BRCA2 Protein

Source

Open in PubMed

Identifiers

PMID: 38636249
DOI: 10.1016/j.ejso.2024.108324

Genes

BRCA1
PALB2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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