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PIK3CA gene mutation status associated with poor prognosis of breast cancer: a retrospective cohort study

27 Feb 2025

Abstract excerpt

PURPOSE: PIK3CA gene mutations have been identified in various malignancies, but the prevalence of specific mutations and their role in breast cancer development remain uncertain. This study aimed to investigate the clinicopathological significance and prognostic impact of PIK3CA mutations in breast cancer. METHODS: Five common PIK3CA mutations (H1047R and H1047L in exon 20, and E542K, E545K, and E545D in exon 9)...

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Advanced Breast Cancer Therapies
BRCA gene mutations in cancer
PI3K/AKT/mTOR signaling in cancer

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 40016671
DOI: 10.1186/s12885-025-13486-5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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