Article
Mutational and expressional association of the PIK3CA gene with the risk of breast cancer in the Pakistani population.
Cellular and molecular biology (Noisy-le-Grand, France) - 15 Nov 2023
Abbasi Samina Asghar, Khan Rashida, Ahmed Mehvish Naseer, Hussain Kashif, Riaz Aayesha, Mansoor Qaisar, Qayyum Mazhar, Mehmood Baig Ruqia
Abstract excerpt
PI3K pathway is a very important pathway that is reported to be involved in breast cancer. Mutation of PI3K and p110 alpha-catalytic subunit of phosphatidylinositol 3-kinase (PIK3CA) is of high predictive and prognostic values in breast cancer. The purpose of the current study was to screen the hotspot mutations of the PIK3CA gene i.e. rs2677760, rs3806685, rs121913273 & rs121913279 along with expressional...
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