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Article

Functional characterization of the GWAS lead SNP rs888663 and effects of GDF15 SNPs on GDF15 levels in gestational hypertension and preeclampsia.

Molecular biology reports - 7 Mar 2026

Pereira Daniela A, Kaihara Julyane N S, Passeti Luis Fernando P, Araújo João Locke F, Souza Renan P, Palei Ana C, Cavalli Ricardo C, Deng Chengyu, Ahituv Nadav, Sandrim Valeria C, Luizon Marcelo R

Abstract excerpt

BACKGROUND: Growth differentiation factor 15 (GDF15) is a biomarker for cardiovascular diseases, and its circulating levels are altered in preeclampsia (PE), which shares mechanisms with cardiovascular diseases. Several SNPs in the GDF15 locus were associated with GDF15 levels, including the GWAS lead SNP rs888663. However, no previous study had performed a functional characterization of rs888663 nor had tested...

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Identifiers

PMID: 41793551
DOI: 10.1007/s11033-026-11629-w
PMCID: PMC12967388

Genes

GDF15
HP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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