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Article

Clinical and genetic correlates of growth differentiation factor 15 in the community.

Clinical chemistry - 1 Nov 2012

Ho Jennifer E, Mahajan Anubha, Chen Ming-Huei, Larson Martin G, McCabe Elizabeth L, Ghorbani Anahita, Cheng Susan, Johnson Andrew D, Lindgren Cecilia M, Kempf Tibor, Lind Lars, Ingelsson Erik, Vasan Ramachandran S, Januzzi James, Wollert Kai C, Morris Andrew P, Wang Thomas J

Abstract excerpt

BACKGROUND: Growth differentiation factor 15 (GDF15), a stress-responsive cytokine produced in cardiovascular cells under conditions of inflammation and oxidative stress, is emerging as an important prognostic marker in individuals with and without existing cardiovascular disease (CVD). We therefore examined the clinical and genetic correlates of circulating GDF15 concentrations, which have not been investigated...

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Identifiers

PMID: 22997280
DOI: 10.1373/clinchem.2012.190322
PMCID: PMC4150608

Genes

GDF15

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