Article
The impact of growth differentiation factor 15 on the risk of cardiovascular diseases: two-sample Mendelian randomization study.
BMC cardiovascular disorders - 28 Oct 2020
Wang Zhuo, Yang Fangkun, Ma Menghuai, Bao Qinyi, Shen Jinlian, Ye Feiming, Xie Xiaojie
Abstract excerpt
BACKGROUND: Growth differentiation factor 15 (GDF-15), a stress responsive cytokine, belongs to transforming growth factor β cytokine superfamily. Some evidence support that it's involved in inflammation, coagulation, oxidative stress, endothelial dysfunction, and hemostasis. However, it's still controversial whether GDF-15 directly contributes to the morbidity and mortality of patients suffered with...
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