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Article

Noncoding SNPs associated with increased GDF15 levels located in a metformin-activated enhancer region upstream of GDF15.

Pharmacogenomics - 1 Jun 2020

Linhares Natália D, Pereira Daniela A, Conceição Izabela McA, Franco Glória R, Eckalbar Walter L, Ahituv Nadav, Luizon Marcelo R

Abstract excerpt

Aim: GDF15 levels are a biomarker for metformin use. We performed the functional annotation of noncoding genome-wide association study (GWAS) SNPs for GDF15 levels and the Genotype-Tissue Expression (GTEx)-expression quantitative trait loci (eQTLs) for GDF15 expression within metformin-activated enhancers around GDF15. Materials & methods: These enhancers were identified using chromatin immunoprecipitation...

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PMID: 32427048
DOI: 10.2217/pgs-2020-0010

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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