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Obesity Polygenic Risk and Healthy Lifestyle Interactions on Weight Trajectories in Women and Men.

Journal of the American Heart Association - 7 Jul 2026

Ghosh Aishi, Lau Meghan, Fernandes Anika, Cade Brian E, Karlson Elizabeth W, Redline Susan, Saxena Richa, Huang Tianyi, Dashti Hassan S

Abstract excerpt

BACKGROUND: Genetics and environmental factors contribute to obesity risk, but the extent to which healthy behaviors can offset genetic susceptibility remains unclear. We examined the interaction between obesity polygenic risk and a composite healthy lifestyle score on body mass index (BMI) trajectories in women and men. METHODS: We analyzed 13 780 women from the Nurses' Health Study and 8242 men from the Health...

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Alcohol Drinking
Body Mass Index
Body Weight
Diet, Healthy
Exercise

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Genetic Risk Score

Healthy Lifestyle

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PMID: 42333656
DOI: 10.1161/JAHA.126.049396

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