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Article

Dietary intervention and BMI reduction in individuals at the extremes of genetic predisposition to higher BMI: a randomized controlled trial.

Nature communications - 13 Jul 2026

Rodosthenous Rodosthenis S, Viiri Leena E, Carson Anne M, Cajuso Tatiana, Corbetta Andrea, Jones Samuel, Brenna Ettore, FinnGen, Makkonen Enni, Virolainen Minttu, Korkeala Niina, Widén Elisabeth, Ripatti Samuli, Ganna Andrea

Abstract excerpt

Genetic susceptibility substantially contributes to inter-individual variation in body mass index (BMI), yet it remains unclear whether genome-wide polygenic risk modifies response to dietary weight loss interventions. We conducted a prospective, randomized controlled trial (GENEROOS) to test whether a BMI polygenic score (PS) interacts with a six-month dietary intervention on BMI change, which was the primary...

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Share to Body Mass Index
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 42443177
DOI: 10.1038/s41467-026-75224-0
PMCID: PMC13486786

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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