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Article

The glycolytic phenotype in carcinogenesis and tumor invasion: insights through mathematical models.

Cancer research - 15 Jul 2003

Gatenby Robert A, Gawlinski Edward T

Abstract excerpt

Malignant cells characteristically exhibit altered metabolic patterns when compared with normal mammalian cells with increased reliance on anaerobic metabolism of glucose to lactic acid even in the presence of abundant oxygen. The inefficiency of the anaerobic pathway is compensated by increased glucose flux, a phenomenon first noted by Otto Warburg approximately 80 years ago and currently exploited for...

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PMID: 12873971

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

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