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Article

Metabolism and its sequelae in cancer evolution and therapy.

Cancer journal (Sudbury, Mass.) - 1 Jan 2000

Gillies Robert J, Gatenby Robert A

Abstract excerpt

Cancers progress through a series of events that can be characterized as "somatic evolution." A central premise of Darwinian evolutionary theory is that the environment imparts pressure to select for species that are most fit within that particular microenvironmental context. Furthermore, the rate of evolution is proportional to both (1) the strength of the environmental selection and (2) the phenotypic variance...

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Identifiers

PMID: 25815848
DOI: 10.1097/PPO.0000000000000102
PMCID: PMC4446699

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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