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Article

Acid treatment of melanoma cells selects for invasive phenotypes.

Clinical & experimental metastasis - 1 Jan 2008

Moellering Raymond E, Black Kvar C, Krishnamurty Chetan, Baggett Brenda K, Stafford Phillip, Rain Matthew, Gatenby Robert A, Gillies Robert J

Abstract excerpt

Solid tumors become acidic due to hypoxia and upregulated glycolysis. We have hypothesized that this acidosis leads to more aggressive invasive behavior during carcinogenesis (Nature Reviews Cancer 4:891-899, 2004). Previous work on this subject has shown mixed results. While some have observed an induction of metastasis and invasion with acid treatments, others have not. To investigate this, human melanoma cells...

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Identifiers

PMID: 18301995
DOI: 10.1007/s10585-008-9145-7

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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