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Article

Bioenergetic and inflammatory systemic phenotypes in Alzheimer's disease APOE ε4-carriers.

Aging cell - 1 May 2021

Wilkins Heather M, Wang Xiaowan, Menta Blaise W, Koppel Scott J, Bothwell Rebecca, Becker Annette M, Anderson Heidi, Schwartz Erin, Pei Dong, Yellapu Nanda K, Chalise Prabhakar, Gouvion Cynthia M, Haeri Mohammad, Burns Jeffrey M, Swerdlow Russell H

Abstract excerpt

We examined the impact of an APOE ε4 genotype on Alzheimer's disease (AD) subject platelet and lymphocyte metabolism. Mean platelet mitochondrial cytochrome oxidase Vmax activity was lower in APOE ε4 carriers and lymphocyte Annexin V, a marker of apoptosis, was significantly higher. Proteins that mediate mitophagy and energy sensing were higher in APOE ε4 lymphocytes which could represent compensatory changes and...

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Source

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Identifiers

PMID: 33939248
DOI: 10.1111/acel.13356
PMCID: PMC8135087

Genes

APOE
ITGA1
SPNS3

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