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Article

PARP-2 catalytic activity drives replication-ICL repair in an allele-specific manner during germline development.

PLoS genetics - 1 Mar 2026

Ren Xiaojing, Hu Anna, Liu Zifei, Kim Semin, Kim Hyun-Min

Abstract excerpt

Maintaining genome integrity in the germline is critical for fertility and organismal survival. Here, we identify C. elegans PARP-2 as an essential and non-redundant regulator of replication-coupled DNA repair. PARP-2 localizes to chromatin during germline development and is also present in the nucleolus; replication stress is associated with changes in its nucleolar distribution, linking fork perturbation to...

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Caenorhabditis elegans
Caenorhabditis elegans Proteins
Cell Nucleolus
Chromatin
DNA Replication

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genomic Instability

Poly(ADP-ribose) Polymerases

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Identifiers

PMID: 41785248
DOI: 10.1371/journal.pgen.1012062
PMCID: PMC12978569

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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