Article
Progression from islet autoimmunity to clinical type 1 diabetes is influenced by genetic factors: results from the prospective TEDDY study.
Journal of medical genetics - 1 Sept 2019
Beyerlein Andreas, Bonifacio Ezio, Vehik Kendra, Hippich Markus, Winkler Christiane, Frohnert Brigitte I, Steck Andrea K, Hagopian William A, Krischer Jeffrey P, Lernmark Åke, Rewers Marian J, She Jin-Xiong, Toppari Jorma, Akolkar Beena, Rich Stephen S, Ziegler Anette-G
Abstract excerpt
BACKGROUND: Progression time from islet autoimmunity to clinical type 1 diabetes is highly variable and the extent that genetic factors contribute is unknown. METHODS: In 341 islet autoantibody-positive children with the human leucocyte antigen (HLA) DR3/DR4-DQ8 or the HLA DR4-DQ8/DR4-DQ8 genotype from the prospective TEDDY (The Environmental Determinants of Diabetes in the Young) study, we investigated whether a...
Topics
- Autoantibodies
- Autoimmunity
- Child
- Child, Preschool
- Diabetes Mellitus, Type 1
- Disease Progression
- Female
- Genetic Predisposition to Disease
- Humans