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Article

IDDM2/insulin VNTR modifies risk conferred by IDDM1/HLA for development of Type 1 diabetes and associated autoimmunity.

Diabetologia - 1 May 2003

Walter M, Albert E, Conrad M, Keller E, Hummel M, Ferber K, Barratt B J, Todd J A, Ziegler A-G, Bonifacio E

Abstract excerpt

AIM/HYPOTHESIS: Type 1 diabetes (T1D) is an autoimmune disease with multiple susceptibility genes. The aim of this study was to determine whether combining IDDM1/HLA and IDDM2/ insulin( INS) 5' variable number of tandem repeat locus (VNTR) genotypes improves T1D risk assessment. METHODS: Patients with T1D (n=488), control subjects (n=846), and offspring of parents with T1D (n=1122) were IDDM1 and IDDM2 genotyped....

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PMID: 12750767
DOI: 10.1007/s00125-003-1082-z

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