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Article

A strategy to find gene combinations that identify children who progress rapidly to type 1 diabetes after islet autoantibody seroconversion.

Acta diabetologica - 1 Jan 2014

Bonifacio Ezio, Krumsiek Jan, Winkler Christiane, Theis Fabian J, Ziegler Anette-Gabriele

Abstract excerpt

We recently developed a novel approach capable of identifying gene combinations to obtain maximal disease risk stratification. Type 1 diabetes has a preclinical phase including seroconversion to autoimmunity and subsequent progression to diabetes. Here, we applied our gene combination approach to identify combinations that contribute either to islet autoimmunity or to the progression from islet autoantibodies to...

Read the complete abstract on PubMed

Topics

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Share to Autoantibodies
Share to Autoimmunity

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to DEAD-box RNA Helicases

Share to HLA-DQ Antigens

Share to Interferon-Induced Helicase, IFIH1

Share to Interleukin-2

Share to Interleukin-2 Receptor alpha Subunit

Share to Islets of Langerhans

Source

Identifiers

PMID: 24249616
DOI: 10.1007/s00592-013-0526-2

Genes

IFIH1
INS
CTLA4
ERBB3
PTPN2
PTPN22

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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A strategy to find gene combinations that identify children who progress rapidly to type 1 diabetes after islet autoantibody seroconversion.PMID 24249616Read ↗

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Genetic scores to stratify risk of developing multiple islet autoantibodies and type 1 diabetes: A prospective study in children.Semantic proximity Read ↗

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Data-Driven Phenotyping of Presymptomatic Type 1 Diabetes Using Longitudinal Autoantibody Profiles.Semantic proximity Read ↗

A Type 1 Diabetes Genetic Risk Score Predicts Progression of Islet Autoimmunity and Development of Type 1 Diabetes in Individuals at Risk.Semantic proximity Read ↗

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Primary islet autoantibody at initial seroconversion and autoantibodies at diagnosis of type 1 diabetes as markers of disease heterogeneity.Semantic proximity Read ↗

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