Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genetic variation at ERBB3/IKZF4 and sexual dimorphism in epitope spreading in single autoantibody-positive relatives.

Diabetologia - 1 Nov 2021

Vandewalle Julie, Van der Auwera Bart J, Amin Henna, Quartier Erik, Desouter Aster K, Tenoutasse Sylvie, Gillard Pieter, De Block Christophe, Keymeulen Bart, Gorus Frans K, Van de Casteele Mark

Abstract excerpt

AIMS/HYPOTHESIS: We examined whether the non-HLA susceptibility locus ERBB3/IKZF4 influences progression of type 1 diabetes stage specifically according to sex. METHODS: SNPs of ERBB3 (rs2292239 T/G) and IKZF4 (rs1701704 G/T) were screened by allelic discrimination quantitative PCR assay in first-degree relatives of type 1 diabetes patients who had developed at least one circulating autoantibody. The effect of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Autoantibodies
Share to Autoantigens
Share to Epitopes
Share to Ikaros Transcription Factor
Share to Proportional Hazards Models
Share to Receptor, ErbB-3
Share to Sex Characteristics
Share to Zinc Transporter 8

Source

Open in PubMed Open full text

Identifiers

PMID: 34448034
DOI: 10.1007/s00125-021-05546-9
PMCID: PMC8494691

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic variation at ERBB3/IKZF4 and sexual dimorphism in epitope spreading in single autoantibody-positive relatives.PMID 34448034Read ↗

Non-HLA Risk Loci ERBB3/IKZF4 and ERBB2/IKZF3/GSDMB/ORMDL3 Interact to Influence Progression of Autoimmunity in Relatives of T1D Patients.Semantic proximity Read ↗

CTLA4, SH2B3, and CLEC16A diversely affect the progression of early islet autoimmunity in relatives of Type 1 diabetes patients.Semantic proximity Read ↗

Accelerated Progression to Type 1 Diabetes in the Presence of HLA-A*24 and -B*18 Is Restricted to Multiple Islet Autoantibody-Positive Individuals With Distinct HLA-DQ and Autoantibody Risk Profiles.Semantic proximity Read ↗

Twenty-Year Progression Rate to Clinical Onset According to Autoantibody Profile, Age, and HLA-DQ Genotype in a Registry-Based Group of Children and Adults With a First-Degree Relative With Type 1 DiabetesSemantic proximity Read ↗

Characterising the age-dependent effects of risk factors on type 1 diabetes progression.Semantic proximity Read ↗

Progression from islet autoimmunity to clinical type 1 diabetes is influenced by genetic factors: results from the prospective TEDDY study.Semantic proximity Read ↗

Non-HLA gene effects on the disease process of type 1 diabetes: From HLA susceptibility to overt disease.Semantic proximity Read ↗

The Influence of Type 1 Diabetes Genetic Susceptibility Regions, Age, Sex, and Family History on the Progression From Multiple Autoantibodies to Type 1 Diabetes: A TEDDY Study Report.Semantic proximity Read ↗

Ethnic differences in progression of islet autoimmunity and type 1 diabetes in relatives at risk.Semantic proximity Read ↗

Autoantibody-defined risk for Type 1 diabetes mellitus in a general population of schoolchildren: results of the Karlsburg Type 1 Diabetes Risk Study after 18 years.Semantic proximity Read ↗

Non-HLA Gene Polymorphisms in the Pathogenesis of Type 1 Diabetes: Phase and Endotype Specific EffectsSemantic proximity Read ↗

Haplotype analysis discriminates genetic risk for DR3-associated endocrine autoimmunity and helps define extreme risk for Addison's disease.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.