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Article

Biased signaling in naturally occurring mutations of G protein-coupled receptors associated with diverse human diseases.

Biochimica et biophysica acta. Molecular basis of disease - 1 Jan 2021

Yang Li-Kun, Hou Zhi-Shuai, Tao Ya-Xiong

Abstract excerpt

G protein-coupled receptors (GPCRs) play critical roles in transmitting a variety of extracellular signals into the cells and regulate diverse physiological functions. Naturally occurring mutations that result in dysfunctions of GPCRs have been known as the causes of numerous diseases. Significant progresses have been made in elucidating the pathophysiology of diseases caused by mutations. The multiple...

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Identifiers

PMID: 32949766
DOI: 10.1016/j.bbadis.2020.165973
PMCID: PMC7722056

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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