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Genetic basis of immune-mediated necrotizing myopathy: A genomic structural equation modeling and AI-driven structural analysis.

Computational biology and chemistry - 1 Aug 2026

Lin Zehong, Wei Jihu, He Xinyu, Chen Yixin, Zhou Honghai

Abstract excerpt

BACKGROUND: Immune-mediated necrotizing myopathy (IMNM) constitutes an autoimmune myopathy precipitated by autoantibodies, marked by rapid progression and recurrent exacerbations, with no approved curative therapies currently available. Genetic determinants serve as pivotal etiological contributors; however, comprehensive genome-wide association study (GWAS) data elucidating IMNM's genetic architecture remain...

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PMID: 41775122
DOI: 10.1016/j.compbiolchem.2026.108982

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