Article
Discovery of new myositis genetic associations through leveraging other immune-mediated diseases.
HGG advances - 10 Oct 2024
Reales Guillermo, Amos Christopher I, Benveniste Olivier, Chinoy Hector, De Bleecker Jan, De Paepe Boel, Doria Andrea, Gregersen Peter K, Lamb Janine A, Limaye Vidya, Lundberg Ingrid E, Machado Pedro M, Maurer Britta, Miller Frederick W, Molberg Øyvind, Pachman Lauren M, Padyukov Leonid, Radstake Timothy R, Reed Ann M, Rider Lisa G, Rothwell Simon, Selva-O'Callaghan Albert, Vencovský Jiri, Wedderburn Lucy R, Wallace Chris
Abstract excerpt
Genome-wide association studies (GWASs) have been successful at finding associations between genetic variants and human traits, including the immune-mediated diseases (IMDs). However, the requirement of large sample sizes for discovery poses a challenge for learning about less common diseases, where increasing volunteer numbers might not be feasible. An example of this is myositis (or idiopathic inflammatory...
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