Article
Genetic Architecture of Idiopathic Inflammatory Myopathies From Meta-Analyses.
Arthritis & rheumatology (Hoboken, N.J.) - 1 Jun 2025
Zhu Catherine, Han Younghun, Byun Jinyoung, Xiao Xiangjun, Rothwell Simon, Miller Frederick W, Lundberg Ingrid E, Gregersen Peter K, Vencovsky Jiri, Shaw Vikram R, McHugh Neil, Limaye Vidya, Selva-O'Callaghan Albert, Hanna Michael G, Machado Pedro M, Pachman Lauren M, Reed Ann M, Rider Lisa G, Molberg Øyvind, Benveniste Olivier, Radstake Timothy, Doria Andrea, De Bleecker Jan L, De Paepe Boel, Maurer Britta, Ollier William E, Padyukov Leonid, Wedderburn Lucy R, Chinoy Hector, Lamb Janine A, Amos Christopher I
Abstract excerpt
OBJECTIVE: Idiopathic inflammatory myopathies (IIMs, myositis) are rare systemic autoimmune disorders that lead to muscle inflammation, weakness, and extramuscular manifestations, with a strong genetic component influencing disease development and progression. Previous genome-wide association studies identified loci associated with IIMs. In this study, we imputed data from two prior genome-wide myositis studies...
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