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Article

Decoding the shared genetic liability of lower respiratory tract infections via genomic structural equation modeling.

BMC pulmonary medicine - 7 Jul 2026

Lei Ying, Li Jin, Xie Jia, Wang Tao

Abstract excerpt

BACKGROUND: Lower respiratory tract infections (LRTI), including pneumonia, tuberculosis, and COVID-19, share overlapping clinical features and risk factors, yet their common genetic architecture remains poorly understood. METHODS: We applied genomic structural equation modeling (Genomic SEM) to dissect the shared genetic susceptibility among seven LRTI-related phenotypes using large-scale GWAS summary...

Read the complete abstract on PubMed

Topics

Humans
Genome-Wide Association Study
Genetic Predisposition to Disease
Respiratory Tract Infections
Bayes Theorem
Phenotype

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Genomics

Polymorphism, Single Nucleotide

NF-kappa B p50 Subunit

Source

Open in PubMed Open full text

Identifiers

PMID: 42410578
DOI: 10.1186/s12890-026-04476-9
PMCID: PMC13602553

Genes

CAMK2D
CNTN5
NFKB1
NUDT6
PKN2
PTPN6
RPL18A
TLK2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 24 Oct 2026.

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