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Article

Dasatinib boosts γδ T cell expansion and memory phenotypes with enhanced antitumor immunity.

Cancer immunology, immunotherapy : CII - 2 Mar 2026

Lin Jeng-Rong, Song Ying-Chyi, Chou Yu-Lun, Chen Yun-Jhen, Hsiao Chi, Li Ju-Pi, Ho Ying-Jui, Liao Wen-Chieh, Yen Hung-Rong, Liu Chiung-Hui

Abstract excerpt

Γδ T cells offer unique advantages in cancer immunotherapy because of their MHC-independent recognition of tumor antigens and innate cytotoxic potential. However, conventional ex vivo expansion protocols using zoledronic acid (Zol) and IL-2 often lead to terminal differentiation and diminished effector function. In this study, we performed a flow cytometry-based screen of an FDA-approved compound library to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Receptors, Antigen, T-Cell, gamma-delta

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Source

Open in PubMed Open full text

Identifiers

PMID: 41770421
DOI: 10.1007/s00262-026-04335-w
PMCID: PMC12953828

Genes

MYC
TCF7
TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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