Article
Dichotomous and stable gamma delta T-cell number and function in healthy individuals.
Journal for immunotherapy of cancer - 1 May 2021
Ou Lingling, Wang Huaishan, Liu Qin, Zhang Jie, Lu Hezhe, Luo Liangping, Shi Changzheng, Lin Shaoqiang, Dong Liyun, Guo Yeye, Huang Lili, Zhu Jinjin, Yin Xiangfan, Huang Alexander C, Karakousis Giorgos, Schuchter Lynn, Amaravadi Ravi, Zheng Cathy, Fan Yi, Guo Wei, Xu Xiaowei
Abstract excerpt
BACKGROUND: Gamma-delta (γδ) T lymphocytes are primed to potently respond to pathogens and transformed cells by recognizing a broad range of antigens. However, adoptive immunotherapy with γδT cells has exhibited mixed treatment responses. Better understanding of γδT cell biology and stratifying healthy donors for allogeneic adoptive therapy is clinically needed to fully realize the therapeutic potential of γδT...
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