Article

PI3Kδ inhibition supports memory T cells with enhanced antitumor fitness

2017-07-20

Abstract excerpt

<h4>SUMMARY</h4> Phosphatidylinositol-3-kinase p110δ (PI3Kδ) inhibition by Idelalisib (CAL-101) in hematological malignancies directly induces apoptosis in cancer cells and disrupts immunological tolerance by depleting regulatory T cells (Tregs). Yet, little is known about the direct impact of PI3Kδ blockade on effector T cells from CAL-101 therapy. Herein, we demonstrate a direct effect of p110δ inactivation via...

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Literature Corpus work: b5dd937e-9bfe-57ea-a09d-eca7e5553cc8
DOI: 10.1101/166074

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