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Article

Linear and Nonlinear Associations Between Lipoprotein(a) and the Risks of Atherosclerotic Cardiovascular Disease.

Circulation journal : official journal of the Japanese Circulation Society - 24 Apr 2026

Hsu Hsin-Yin, Fan Hsien-Yu, Tsai Ming-Chieh, Lai Chih-Jun, Hwang Lee-Ching, Chien Kuo-Liong

Abstract excerpt

BACKGROUND: Lipoprotein(a) [Lp(a)] is a recognized risk factor for atherosclerotic cardiovascular disease (ASCVD), but the shape and potential nonlinearity of its association remain uncertain. We assessed the linear and nonlinear associations between Lp(a) levels and ASCVD risk using observational and Mendelian randomization (MR) approaches. METHODS AND RESULTS: We analyzed 351,858 UK Biobank participants...

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Identifiers

PMID: 41765385
DOI: 10.1253/circj.CJ-25-0847

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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